Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development
نویسندگان
چکیده
منابع مشابه
Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development.
Previously, we have reported that neutralization of surface lymphotoxin (LT-alphabeta) in mice which expressed an LT-beta receptor-Fc fusion protein, driven by the cytomegalovirus promoter, resulted in an array of anatomic abnormalities. We now report that mice which express a tumor necrosis factor (TNF) receptor p60-Fc fusion protein (which neutralizes TNF and soluble LT-alpha3 activity) devel...
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Tumor necrosis factor (TNF)' and lymphotoxin (LT) are two partially homologous factors originally described on the basis of their cytotoxic or cytostatic effects on tumor cell lines (1-3). Purification studies and cloning of genes for TNF and LT have allowed more detailed studies of the biology of these factors (4-8). In addition to their cytotoxic activity, TNF and LT exert regulatory effects ...
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Lymphotoxin alpha (LTalpha) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin beta receptor (LTbetaR) as a heterotrimeric LTalpha1beta2 complex. LTalpha-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LTbeta-deficient mice and TNFR-deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LTbet...
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ژورنال
عنوان ژورنال: International Immunology
سال: 1998
ISSN: 1460-2377
DOI: 10.1093/intimm/10.6.727